| Pair Name | Capsaicin, Fluorouracil | ||
| Phytochemical Name | Capsaicin (PubChem CID: 1548943 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Capsaicin, Fluorouracil | |||
| Disease Info | [ICD-11: 2C17] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Autophagy | |||
| Gene Regulation | Up-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | ATG3 | hsa64422 | |
| Down-regulation | Expression | BECN1 | hsa8678 | |
| Up-regulation | Expression | MAP1LC3A | hsa84557 | |
| Up-regulation | Phosphorylation | RPS6KB1 | hsa6198 | |
| In Vitro Model | QBC939 | Cholangiocarcinoma | Homo sapiens (Human) | CVCL_6942 |
| Mz-ChA-1 | Gallbladder carcinoma | Homo sapiens (Human) | CVCL_6932 | |
| SK-ChA-1 | Cholangiocarcinoma | Homo sapiens (Human) | CVCL_6952 | |
| Result | These results demonstrate that capsaicin may be a useful adjunct therapy to improve chemosensitivity in CCA. This effect likely occurs via PI3K/AKT/mTOR pathway activation, suggesting a promising strategy for the development of combination drugs for CCA. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Capsaicin Enhances the Drug Sensitivity of Cholangiocarcinoma through the Inhibition of Chemotherapeutic-Induced Autophagy. PLoS One. 2015 May 1;10(5):e0121538. doi: 10.1371/journal.pone.0121538. | Click |
